An In-Silico Approach to Confront Monoamine Oxidase by Synthetic and Herbal Antidepressant Drug
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چکیده
Monoamine oxidase (MAO) is an enzyme that metabolizes monoamines, and are also vital to
منابع مشابه
An In-Silico Approach to Confront Monoamine Oxidase by Synthetic and Herbal Antidepressant Drug
Monoamine oxidase (MAO) is an enzyme that metabolizes monoamines, and are also vital to
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To develop a new more accurate spectrophotometric method for detecting monoamine oxidase inhibitors from plant extracts, a series of amine substrates were selected and their ability to be oxidized by monoamine oxidase was evaluated by the HPLC method and a new substrate was used to develop a peroxidase-linked spectrophotometric assay. 4-(Trifluoromethyl) benzylamine (11) was proved to be an exc...
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Moclobemide is a selective and reversible monoamine oxidase-A inhibitor, which is used as an antidepressant. Three moclobemide analogues were synthesized by replacing moclobemide phenyl ring with substituted imidazoles. So, N-[(4-morpholinyl) ethyl)]-1-benzyl-2-(alkylthio)-1H-imidazole-5-carboxamides (7a-c) were synthesized and studied for the antidepressant activity using forced swimming test ...
متن کاملSynthesis and Antidepressant Activity of N-Substituted Imidazole-5-Carboxamides in Forced Swimming Test Model
Moclobemide is a selective and reversible monoamine oxidase-A inhibitor, which is used as an antidepressant. Three moclobemide analogues were synthesized by replacing moclobemide phenyl ring with substituted imidazoles. So, N-[(4-morpholinyl) ethyl)]-1-benzyl-2-(alkylthio)-1H-imidazole-5-carboxamides (7a-c) were synthesized and studied for the antidepressant activity using forced swimming test ...
متن کاملA Peroxidase-linked Spectrophotometric Assay for the Detection of Monoamine Oxidase Inhibitors
To develop a new more accurate spectrophotometric method for detecting monoamine oxidase inhibitors from plant extracts, a series of amine substrates were selected and their ability to be oxidized by monoamine oxidase was evaluated by the HPLC method and a new substrate was used to develop a peroxidase-linked spectrophotometric assay. 4-(Trifluoromethyl) benzylamine (11) was proved to be an exc...
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